Hydroxychloroquine and azithromycin alter the contractility of living porcine heart slices

Hydroxychloroquine and azithromycin alter the contractility of living porcine heart slices

The cardiotoxicity risk of hydroxychloroquine (HCQ) and azithromycin (AZM) has been the subject of intensive research triggered by safety concerns in COVID-19 patients. HCQ and AZM have been associated with QT interval prolongation and drug-induced arrhythmias, however other cardiotoxicity mechanism...

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Bibliographic Details
Main Authors: Qin Wu, Abigail J. Ross, Tugce Ipek, Georgina H. Thompson, Robert D. Johnson, Changhao Wu, Patrizia Camelliti
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Pharmacology
Subjects:
myocardial slices
organotypic ex-vivo models
COVID-19
cardiotoxicity
safety pharmacology
calcium channels
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1127388/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1127388/full

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