Hydroxychloroquine and azithromycin alter the contractility of living porcine heart slices

Hydroxychloroquine and azithromycin alter the contractility of living porcine heart slices

The cardiotoxicity risk of hydroxychloroquine (HCQ) and azithromycin (AZM) has been the subject of intensive research triggered by safety concerns in COVID-19 patients. HCQ and AZM have been associated with QT interval prolongation and drug-induced arrhythmias, however other cardiotoxicity mechanism...

Full description

Bibliographic Details
Main Authors:	Qin Wu, Abigail J. Ross, Tugce Ipek, Georgina H. Thompson, Robert D. Johnson, Changhao Wu, Patrizia Camelliti
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-05-01
Series:	Frontiers in Pharmacology
Subjects:	myocardial slices organotypic ex-vivo models COVID-19 cardiotoxicity safety pharmacology calcium channels
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1127388/full

Similar Items

A novel method to extend viability and functionality of living heart slices
by: Abigail J. Ross, et al.
Published: (2023-10-01)

Porcine Organotypic Epicardial Slice Protocol: A Tool for the Study of Epicardium in Cardiovascular Research
by: Davide Maselli, et al.
Published: (2022-07-01)

Lung Organotypic Slices Enable Rapid Quantification of Acute Radiotherapy Induced Toxicity
by: Maxime Dubail, et al.
Published: (2023-10-01)

Ex Vivo Functional Assay for Evaluating Treatment Response in Tumor Tissue of Head and Neck Squamous Cell Carcinoma
by: Marta E. Capala, et al.
Published: (2023-01-01)

Organotypic Hippocampal Slice Cultures from Adult Tauopathy Mice and Theragnostic Evaluation of Nanomaterial Phospho-TAU Antibody-Conjugates
by: Susanna Kemppainen, et al.
Published: (2023-05-01)

Proinflammatory and cytotoxic response to nanoparticles in precision-cut lung slices
by: Stephanie Hirn, et al.
Published: (2014-12-01)

Human Precision-Cut Liver Slices: A Potential Platform to Study Alcohol-Related Liver Disease
by: Una Rastovic, et al.
Published: (2023-12-01)

Ex Vivo Rat Transected Spinal Cord Slices as a Model to Assess Lentiviral Vector Delivery of Neurotrophin-3 and Short Hairpin RNA against NG2
by: Azim Patar, et al.
Published: (2020-03-01)

Ex vivo infection of murine precision-cut lung tissue slices with Mycobacterium abscessus: a model to study antimycobacterial agents
by: Carmen Amelia Molina-Torres, et al.
Published: (2020-11-01)

High phenylalanine concentrations induce demyelination and microglial activation in mouse cerebellar organotypic slices
by: Orli Thau-Zuchman, et al.
Published: (2022-09-01)

Glioblastoma-Derived Three-Dimensional Ex Vivo Models to Evaluate Effects and Efficacy of Tumor Treating Fields (TTFields)
by: Vera Nickl, et al.
Published: (2022-10-01)

Spreading of Beta-Amyloid in Organotypic Mouse Brain Slices and Microglial Elimination and Effects on Cholinergic Neurons
by: Kurt Moelgg, et al.
Published: (2021-03-01)

Precision-Cut Tumor Slices (PCTS) as an Ex Vivo Model in Immunotherapy Research
by: Paraskevi Dimou, et al.
Published: (2022-04-01)

Using Organotypic Tissue Slices to Investigate the Microenvironment of Pancreatic Cancer: Pharmacotyping and Beyond
by: Jonathan Robert Weitz, et al.
Published: (2021-10-01)

Organotypic tumor slice cultures provide a versatile platform for immuno-oncology and drug discovery
by: Ramya Sivakumar, et al.
Published: (2019-12-01)

Comparative analysis of adeno-associated virus serotypes for gene transfer in organotypic heart slices
by: Zihou Liu, et al.
Published: (2020-11-01)

Spreading of P301S Aggregated Tau Investigated in Organotypic Mouse Brain Slice Cultures
by: Dhwani S. Korde, et al.
Published: (2022-08-01)

Organotypic brain slice culture promotes the transformation of haemopoietic
by: Roya Lari, et al.
Published: (2012-06-01)

Chronic Treatment of Ascorbic Acid Leads to Age-Dependent Neuroprotection against Oxidative Injury in Hippocampal Slice Cultures
by: Kyung Hee Lee, et al.
Published: (2021-02-01)

Deposition pattern and subcellular distribution of disease-associated prion protein in cerebellar organotypic slice cultures infected with scrapie
by: Hanna eWolf, et al.
Published: (2015-11-01)

Melatonin Activates Anti-Inflammatory Features in Microglia in a Multicellular Context: Evidence from Organotypic Brain Slices and HMC3 Cells
by: Sara Merlo, et al.
Published: (2023-02-01)

Organotypic brain slice cultures to model neurodegenerative proteinopathies
by: C. L. Croft, et al.
Published: (2019-12-01)

Culture of vibrating microtome tissue slices as a 3D model in biomedical research
by: Fatina Siwczak, et al.
Published: (2023-06-01)

Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates
by: Sara Elfarrash, et al.
Published: (2019-12-01)

A ferret brain slice model of oxygen–glucose deprivation captures regional responses to perinatal injury and treatment associated with specific microglial phenotypes
by: Thomas R. Wood, et al.
Published: (2022-05-01)

Application of Precision-Cut Lung Slices as an In Vitro Model for Research of Inflammatory Respiratory Diseases
by: Yan Liu, et al.
Published: (2022-12-01)

The Biological Behaviors of Neural Stem Cell Affected by Microenvironment from Host Organotypic Brain Slices under Different Conditions
by: Qian Jiao, et al.
Published: (2023-02-01)

An advanced glioma cell invasion assay based on organotypic brain slice cultures
by: Tanja Eisemann, et al.
Published: (2018-01-01)

Beta-Amyloid Enhances Vessel Formation in Organotypic Brain Slices Connected to Microcontact Prints
by: Katharina Steiner, et al.
Published: (2023-12-01)

Ex vivo model of epilepsy in organotypic slices—a new tool for drug screening
by: Daniela M. Magalhães, et al.
Published: (2018-07-01)

Organotypic whole hemisphere brain slice models to study the effects of donor age and oxygen-glucose-deprivation on the extracellular properties of cortical and striatal tissue
by: Michael McKenna, et al.
Published: (2022-06-01)

Exposure of α-Synuclein Aggregates to Organotypic Slice Cultures Recapitulates Key Molecular Features of Parkinson's Disease
by: Serge Moudio, et al.
Published: (2022-02-01)

Spreading of Aggregated α-Synuclein in Sagittal Organotypic Mouse Brain Slices
by: Buket Uçar, et al.
Published: (2022-01-01)

Glutamate Receptor-Mediated Neurotoxicity in a Model of Ethanol Dependence and Withdrawal in Rat Organotypic Hippocampal Slice Cultures
by: Elisabetta Gerace, et al.
Published: (2019-01-01)

POSCAbilities: The Application of the Prion Organotypic Slice Culture Assay to Neurodegenerative Disease Research
by: Hailey Pineau, et al.
Published: (2020-07-01)

Human precision-cut cystic duct and gallbladder slices: a novel method for studying cholangiopathies
by: Jeske Fridrichs, et al.
Published: (2023-07-01)

A Combination of Heavy Metals and Intracellular Pathway Modulators Induces Alzheimer Disease-like Pathologies in Organotypic Brain Slices
by: Dhwani S. Korde, et al.
Published: (2024-01-01)

Glioblastoma Tissue Slice Tandem-Cultures for Quantitative Evaluation of Inhibitory Effects on Invasion and Growth
by: Vasile Sidorcenco, et al.
Published: (2020-09-01)

Applying Tissue Slice Culture in Cancer Research—Insights from Preclinical Proton Radiotherapy
by: Theresa Suckert, et al.
Published: (2020-06-01)

Early Age- and Sex-Dependent Regulation of Astrocyte-Mediated Glutamatergic Synapse Elimination in the Rat Prefrontal Cortex: Establishing an Organotypic Brain Slice Culture Investigating Tool
by: Eugenia Vivi, et al.
Published: (2023-12-01)