Hydroxychloroquine and azithromycin alter the contractility of living porcine heart slices

Hydroxychloroquine and azithromycin alter the contractility of living porcine heart slices

The cardiotoxicity risk of hydroxychloroquine (HCQ) and azithromycin (AZM) has been the subject of intensive research triggered by safety concerns in COVID-19 patients. HCQ and AZM have been associated with QT interval prolongation and drug-induced arrhythmias, however other cardiotoxicity mechanism...

Descripción completa

Detalles Bibliográficos
Autores principales: Qin Wu, Abigail J. Ross, Tugce Ipek, Georgina H. Thompson, Robert D. Johnson, Changhao Wu, Patrizia Camelliti
Formato: Artículo
Lenguaje:English
Publicado: Frontiers Media S.A. 2023-05-01
Colección:Frontiers in Pharmacology
Materias:
myocardial slices
organotypic ex-vivo models
COVID-19
cardiotoxicity
safety pharmacology
calcium channels
Acceso en línea:https://www.frontiersin.org/articles/10.3389/fphar.2023.1127388/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1127388/full

Ejemplares similares