Plasmid-based generation of neural cells from human fibroblasts using non-integrating episomal vectors

Plasmid-based generation of neural cells from human fibroblasts using non-integrating episomal vectors

Differentiation of human fibroblasts into functional neurons depends on the introduction of viral-mediated transcription factors, which present risks of viral gene integration and tumorigenicity. In recent years, although some studies have been successful in directly inducing neurons through sustain...

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Bibliographic Details
Main Authors: Shao-Bing Dai, Ting Shen, Ting-Ting Zheng, Jia-Li Pu, Xin-Zhong Chen
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; induced neurons; plasmid-based; human fibroblasts; nucleofection; Ascl1; miR124; p53; reprogramming; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=3;spage=501;epage=505;aulast=Dai

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=3;spage=501;epage=505;aulast=Dai

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