Pan-neutralizing, germline-encoded antibodies against SARS-CoV-2: Addressing the long-term problem of escape variants

Pan-neutralizing, germline-encoded antibodies against SARS-CoV-2: Addressing the long-term problem of escape variants

Despite the initially reported high efficacy of vaccines directed against ancestral SARS-CoV-2, repeated infections in both unvaccinated and vaccinated populations remain a major global health challenge. Because of mutation-mediated immune escape by variants-of-concern (VOC), approved neutralizing a...

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Bibliographic Details
Main Authors: Justin Mark Lunderberg, Sanjucta Dutta, Ai-Ris Y. Collier, Jeng-Shin Lee, Yen-Ming Hsu, Qiao Wang, Weina Zheng, Shushun Hao, Haohai Zhang, Lili Feng, Simon C. Robson, Wenda Gao, Stefan Riedel
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
neutralizing antibodies
somatic hypermutation
B cell memory
vaccines
IgM
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1032574/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1032574/full

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