Functional rare variants influence the clinical response to anti-TNF therapy in Crohn’s disease

Functional rare variants influence the clinical response to anti-TNF therapy in Crohn’s disease

Background: The effect of low-frequency functional variation on anti-tumor necrosis factor alpha (TNF) response in Crohn’s disease (CD) patients remains unexplored. The objective of this study was to investigate the impact of functional rare variants in clinical response to anti-TNF therapy in CD. M...

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Main Authors: María Chaparro, Adrià Aterido, Iván Guerra, Marisa Iborra, Jose Luis Cabriada, Luis Bujanda, Carlos Taxonera, Valle García-Sánchez, Ignacio Marín-Jiménez, Manuel Barreiro-de Acosta, Isabel Vera, Maria Dolores Martín-Arranz, Borja Hernández-Breijo, Francisco Mesonero, Laura Sempere, Fernando Gomollón, Joaquín Hinojosa, Fernando Bermejo, Belén Beltrán, Ainhoa Rodríguez-Pescador, Jesús María Banales, David Olivares, Patricia Aguilar-Melero, Luis Menchén, Rocío Ferreiro-Iglesias, Isabel Blazquez Gómez, Beatriz Benitez García, Luis G Guijarro, Alicia C Marin, David Bernardo, Sara Marsal, Antonio Julia, Javier P Gisbert
Format: Article
Language:English
Published: SAGE Publishing 2019-09-01
Series:Therapeutic Advances in Gastroenterology
Online Access:https://doi.org/10.1177/1756284819867848

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https://doi.org/10.1177/1756284819867848

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