Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein <it>in vivo</it>

Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein <it>in vivo</it>

<p>Abstract</p> <p>Background</p> <p>The cellular prion protein (PrP<sup>C</sup>) fulfils several yet not completely understood physiological functions. Apart from these functions, it has the ability to misfold into a pathogenic scrapie form (PrP<sup>S...

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Detalles Bibliográficos
Main Authors: Petrowitz Bettina, Jorissen Ellen, Thurm Dana, Bernreuther Christian, Kluth Mark A, Puig Berta, Prox Johannes, Altmeppen Hermann C, Bartsch Udo, De Strooper Bart, Saftig Paul, Glatzel Markus
Formato: Artigo
Idioma:English
Publicado: BMC 2011-05-01
Series:Molecular Neurodegeneration
Acceso en liña:http://www.molecularneurodegeneration.com/content/6/1/36

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