Site-Selective Artificial Ribonucleases: Renaissance of Oligonucleotide Conjugates for Irreversible Cleavage of RNA Sequences

Site-Selective Artificial Ribonucleases: Renaissance of Oligonucleotide Conjugates for Irreversible Cleavage of RNA Sequences

RNA-targeting therapeutics require highly efficient sequence-specific devices capable of RNA irreversible degradation in vivo. The most developed methods of sequence-specific RNA cleavage, such as siRNA or antisense oligonucleotides (ASO), are currently based on recruitment of either intracellular m...

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Bibliographic Details
Main Authors: Yaroslav Staroseletz, Svetlana Gaponova, Olga Patutina, Elena Bichenkova, Bahareh Amirloo, Thomas Heyman, Daria Chiglintseva, Marina Zenkova
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Molecules
Subjects:
artificial ribonuclease
oligonucleotide-peptide conjugate
RNA cleavage
neocuproine
Tris(2-aminobenzimidazole)
PNAzyme
Online Access:https://www.mdpi.com/1420-3049/26/6/1732

Internet

https://www.mdpi.com/1420-3049/26/6/1732

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