Endocrine Therapy-Resistant Breast Cancer Cells Are More Sensitive to Ceramide Kinase Inhibition and Elevated Ceramide Levels Than Therapy-Sensitive Breast Cancer Cells

Endocrine Therapy-Resistant Breast Cancer Cells Are More Sensitive to Ceramide Kinase Inhibition and Elevated Ceramide Levels Than Therapy-Sensitive Breast Cancer Cells

ET resistance is a critical problem for estrogen receptor-positive (ER+) breast cancer. In this study, we have investigated how alterations in sphingolipids promote cell survival in ET-resistant breast cancer. We have performed LC-MS-based targeted sphingolipidomics of tamoxifen-sensitive and -resis...

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Bibliographic Details
Main Authors: Purab Pal, Alec Millner, Svetlana E. Semina, Rosemary J. Huggins, Logan Running, Diana S. Aga, Debra A. Tonetti, Rachel Schiff, Geoffrey L. Greene, G. Ekin Atilla-Gokcumen, Jonna Frasor
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cancers
Subjects:
ceramide
ceramide kinase
sphingolipid profiling
endocrine therapy resistance
breast cancer
ceramide-1-phosphate
Online Access:https://www.mdpi.com/2072-6694/14/10/2380

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https://www.mdpi.com/2072-6694/14/10/2380

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