Evaluation of a 4-day repeated-dose micronucleus test in rat glandular stomach and colon using aneugens and non-genotoxic non-carcinogens

Evaluation of a 4-day repeated-dose micronucleus test in rat glandular stomach and colon using aneugens and non-genotoxic non-carcinogens

Abstract Background We previously developed a rodent gastrointestinal (GI) tract micronucleus (MN) test using the glandular stomach and/or colon, and evaluated this test method using several genotoxic carcinogens (clastogens) and genotoxic non-carcinogens; we demonstrated that this test method could...

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Bibliographic Details
Main Authors: Emiko Okada, Yohei Fujiishi, Kazunori Narumi, Wakako Ohyama
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Genes and Environment
Subjects:
Micronucleus test
Gastrointestinal tract
Glandular stomach
Colon
4-day treatment regimen
Aneugen
Online Access:https://doi.org/10.1186/s41021-022-00241-6

Internet

https://doi.org/10.1186/s41021-022-00241-6

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