Glaucocalyxin A Inhibits the Malignant Progression of Epithelial Ovarian Cancer by Affecting the MicroRNA-374b-5p/HMGB3/Wnt-β-Catenin Pathway Axis

Glaucocalyxin A Inhibits the Malignant Progression of Epithelial Ovarian Cancer by Affecting the MicroRNA-374b-5p/HMGB3/Wnt-β-Catenin Pathway Axis

ObjectiveGlaucocalyxin A (GLA) is an ent-kaurene diterpenoid from Rabdosia japonica var possessing anti-tumor activity. This study aimed to investigate effects of GLA on epithelial ovarian cancer (EOC) and elucidate underlying mechanisms.MethodsThe expression of HMGB3 in EOC tissues was analyzed by...

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Bibliographic Details
Main Authors: Feng Chen, Fang Sun, Xia Liu, Jing Shao, Bei Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Oncology
Subjects:
glaucocalyxin A
high-mobility group box 3
epithelial ovarian cancer
microRNA-374b-5p
Wnt-β-catenin pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.955830/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.955830/full

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