Endothelial activation and fibrotic changes are impeded by laminar flow-induced CHK1-SENP2 activity through mechanisms distinct from endothelial-to-mesenchymal cell transition

Endothelial activation and fibrotic changes are impeded by laminar flow-induced CHK1-SENP2 activity through mechanisms distinct from endothelial-to-mesenchymal cell transition

BackgroundThe deSUMOylase sentrin-specific isopeptidase 2 (SENP2) plays a crucial role in atheroprotection. However, the phosphorylation of SENP2 at T368 under disturbed flow (D-flow) conditions hinders its nuclear function and promotes endothelial cell (EC) activation. SUMOylation has been implicat...

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Main Authors: Minh T. H. Nguyen, Masaki Imanishi, Shengyu Li, Khanh Chau, Priyanka Banerjee, Loka reddy Velatooru, Kyung Ae Ko, Venkata S. K. Samanthapudi, Young J. Gi, Ling-Ling Lee, Rei J. Abe, Elena McBeath, Anita Deswal, Steven H. Lin, Nicolas L. Palaskas, Robert Dantzer, Keigi Fujiwara, Mae K. Borchrdt, Estefani Berrios Turcios, Elizabeth A. Olmsted-Davis, Sivareddy Kotla, John P. Cooke, Guangyu Wang, Jun-ichi Abe, Nhat-Tu Le
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
atherosclerosis
endothelial activation
laminar flow
CHK1
SENP2
SUMOylation
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2023.1187490/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2023.1187490/full

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