NF-κB System Is Chronically Activated and Promotes Glomerular Injury in Experimental Type 1 Diabetic Kidney Disease

NF-κB System Is Chronically Activated and Promotes Glomerular Injury in Experimental Type 1 Diabetic Kidney Disease

High glucose concentration can activate TLR4 and NF-κB, triggering the production of proinflammatory mediators. We investigated whether the NF-κB pathway is involved in the pathogenesis and progression of experimental diabetic kidney disease (DKD) in a model of long-term type 1 diabetes mellitus (DM...

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Bibliographic Details
Main Authors: Orestes Foresto-Neto, Amanda Helen Albino, Simone Costa Alarcon Arias, Viviane Dias Faustino, Fernanda Florencia Fregnan Zambom, Marcos Antonio Cenedeze, Rosilene Motta Elias, Denise Maria Avancini Costa Malheiros, Niels Olsen Saraiva Camara, Clarice Kazue Fujihara, Roberto Zatz
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Physiology
Subjects:
diabetic kidney disease
glomerulosclerosis
NF-κB
innate immunity
pyrrolidine dithiocarbamate
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00084/full

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https://www.frontiersin.org/article/10.3389/fphys.2020.00084/full

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