CRISPR Editing Enables Consequential Tag-Activated MicroRNA-Mediated Endogene Deactivation

CRISPR Editing Enables Consequential Tag-Activated MicroRNA-Mediated Endogene Deactivation

Molecular therapies and functional studies greatly benefit from spatial and temporal precision of genetic intervention. We therefore conceived and explored tag-activated microRNA (miRNA)-mediated endogene deactivation (TAMED) as a research tool and potential lineage-specific therapy. For proof of pr...

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Bibliographic Details
Main Authors: Panayiota L. Papasavva, Petros Patsali, Constantinos C. Loucari, Ryo Kurita, Yukio Nakamura, Marina Kleanthous, Carsten W. Lederer
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
gene tagging
cell/tissue-type-specific gene therapy
γ-globin induction
hemoglobinopathies
BCL11A
erythroid-specific
Online Access:https://www.mdpi.com/1422-0067/23/3/1082

Internet

https://www.mdpi.com/1422-0067/23/3/1082

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