The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factor

<p>Abstract</p> <p>Background</p> <p>Huntington's disease (HD) pathogenesis is due to an expanded polyglutamine tract in huntingtin, but the specificity of neuronal loss compared with other polyglutamine disorders also implies a role for the protein's unknown...

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Bibliographic Details
Main Authors: Gusella James F, Takano Hiroki
Format: Article
Language:English
Published: BMC 2002-10-01
Series:BMC Neuroscience
Online Access:http://www.biomedcentral.com/1471-2202/3/15