Near-infrared photoimmunotherapy targeting GPR87: Development of a humanised anti-GPR87 mAb and therapeutic efficacy on a lung cancer mouse model

Near-infrared photoimmunotherapy targeting GPR87: Development of a humanised anti-GPR87 mAb and therapeutic efficacy on a lung cancer mouse model

Background: GPR87 is a G-protein receptor that is specifically expressed in tumour cells, such as lung cancer, and rarely expressed in normal cells. GPR87 is a promising target for cancer therapy, but its ligand is controversial. Near-infrared photoimmunotherapy (NIR-PIT) is a novel cancer therapy i...

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Bibliographic Details
Main Authors: Hirotoshi Yasui, Yuko Nishinaga, Shunichi Taki, Kazuomi Takahashi, Yoshitaka Isobe, Misae Shimizu, Chiaki Koike, Tetsuro Taki, Aya Sakamoto, Keiko Katsumi, Keisuke Ishii, Kazuhide Sato
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:EBioMedicine
Subjects:
Near infrared photoimmunotherapy
IRDye700
Malignant pleural mesothelioma
Lung cancer
GPR87
G-protein receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421001651

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http://www.sciencedirect.com/science/article/pii/S2352396421001651

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