Opposite Effects of Moderate and Extreme Cx43 Deficiency in Conditional Cx43-Deficient Mice on Angiotensin II-Induced Cardiac Fibrosis

Opposite Effects of Moderate and Extreme Cx43 Deficiency in Conditional Cx43-Deficient Mice on Angiotensin II-Induced Cardiac Fibrosis

Connexin 43 (Cx43) is essential for cardiac electrical coupling, but its effects on myocardial fibrosis is controversial. Here, we analyzed the role of Cx43 in myocardial fibrosis caused by angiotensin II (AngII) using Cx43<sup>fl/fl</sup> and Cx43<sup>Cre-ER(T)/fl</sup> indu...

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Bibliographic Details
Main Authors: Laura Valls-Lacalle, Corall Negre-Pujol, Cristina Rodríguez, Saray Varona, Antoni Valera-Cañellas, Marta Consegal, Jose Martínez-González, Antonio Rodríguez-Sinovas
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cells
Subjects:
angiotensin ii
fibrosis
collagen
connexin 43
hypertrophy
Online Access:https://www.mdpi.com/2073-4409/8/10/1299

Internet

https://www.mdpi.com/2073-4409/8/10/1299

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