PI3K-AKT, JAK2-STAT3 pathways and cell–cell contact regulate maspin subcellular localization

PI3K-AKT, JAK2-STAT3 pathways and cell–cell contact regulate maspin subcellular localization

Abstract Background Maspin (SERPINB5) is a potential tumor suppressor gene with pleiotropic biological activities, including regulation of cell proliferation, death, adhesion, migration and gene expression. Several studies indicate that nuclear localization is essential for maspin tumor suppression...

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Bibliographic Details
Main Authors: M. T. Longhi, L. E. Silva, M. Pereira, M. Magalhães, J. Reina, F. N. L. Vitorino, B. M. Gumbiner, J. P. C. da Cunha, N. Cella
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Cell Communication and Signaling
Subjects:
Maspin
EGFR
PI3K-AkT
JAK2-STAT3
Cell-to-cell contact
Online Access:https://doi.org/10.1186/s12964-021-00758-3

Internet

https://doi.org/10.1186/s12964-021-00758-3

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