Novel Alzheimer risk factor IQ motif containing protein K is abundantly expressed in the brain and is markedly increased in patients with Alzheimer’s disease

Novel Alzheimer risk factor IQ motif containing protein K is abundantly expressed in the brain and is markedly increased in patients with Alzheimer’s disease

Alzheimer’s disease (AD) is complex and highly heterogeneous. Less than 10% of AD cases are early-onset (EOAD) caused by autosomal dominantly inherited mutations in amyloid precursor protein (APP), presenilin 1 (PS1), or presenilin 2 (PS2), each of which can increase Aβ generation and, thus, amyloid...

Full description

Bibliographic Details
Main Authors: Hongjie Wang, Dinesh Devadoss, Madhavan Nair, Hitendra S. Chand, Madepalli K. Lakshmana
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
IQCK
Alzheimer’s disease
brain regions
neurons
microglia
oligodendrocytes
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.954071/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2022.954071/full

Similar Items