Relationship of MMP-14 and TIMP-3 Expression with Macrophage Activation and Human Atherosclerotic Plaque Vulnerability

Relationship of MMP-14 and TIMP-3 Expression with Macrophage Activation and Human Atherosclerotic Plaque Vulnerability

Matrix metalloproteinase-14 (MMP-14) promotes vulnerable plaque morphology in mice, whereas tissue inhibitor of metalloproteinases-3 (TIMP-3) overexpression is protective. MMP-14hi  TIMP-3lo rabbit foam cells are more invasive and more prone to apoptosis than MMP-14lo  TIMP-3hi cells. We investigate...

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Bibliographic Details
Main Authors: Jason L. Johnson, Nicholas P. Jenkins, Wei-Chun Huang, Karina Di Gregoli, Graciela B. Sala-Newby, Vincent P. W. Scholtes, Frans L. Moll, Gerard Pasterkamp, Andrew C. Newby
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2014/276457

Internet

http://dx.doi.org/10.1155/2014/276457

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