Simulation of spontaneous G protein activation reveals a new intermediate driving GDP unbinding

Simulation of spontaneous G protein activation reveals a new intermediate driving GDP unbinding

Activation of heterotrimeric G proteins is a key step in many signaling cascades. However, a complete mechanism for this process, which requires allosteric communication between binding sites that are ~30 Å apart, remains elusive. We construct an atomically detailed model of G protein activation by...

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Bibliographic Details
Main Authors: Xianqiang Sun, Sukrit Singh, Kendall J Blumer, Gregory R Bowman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-10-01
Series:eLife
Subjects:
molecular dynamics
allostery
G proteins
Markov state models
Online Access:https://elifesciences.org/articles/38465

Internet

https://elifesciences.org/articles/38465

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