Unveiling the affinity–stability relationship in anti-measles virus antibodies: a computational approach for hotspots prediction

Unveiling the affinity–stability relationship in anti-measles virus antibodies: a computational approach for hotspots prediction

Recent years have seen an uptick in the use of computational applications in antibody engineering. These tools have enhanced our ability to predict interactions with antigens and immunogenicity, facilitate humanization, and serve other critical functions. However, several studies highlight the conce...

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Bibliographic Details
Main Authors: Rimpa Paul, Keisuke Kasahara, Jiei Sasaki, Jorge Fernández Pérez, Ryo Matsunaga, Takao Hashiguchi, Daisuke Kuroda, Kouhei Tsumoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Molecular Biosciences
Subjects:
antibody engineering
computer-aided design
measles virus hemagglutinin
hotspots
relative hydropathy
molecular dynamics
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1302737/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1302737/full

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