Experimental analysis of bladder cancer-associated mutations in EP300 identifies EP300-R1627W as a driver mutation

Experimental analysis of bladder cancer-associated mutations in EP300 identifies EP300-R1627W as a driver mutation

Abstract Background Bladder cancer (BCa) is the most common malignant tumor of the urinary system, with transitional cell carcinoma (TCC) being the predominant type. EP300 encodes a lysine acetyltransferase that regulates a large subset of genes by acetylating histones and non-histone proteins. We p...

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Bibliographic Details
Main Authors: Mayao Luo, Yifan Zhang, Zhuofan Xu, Shidong Lv, Qiang Wei, Qiang Dang
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Molecular Medicine
Subjects:
EP300
Bladder cancer
Missense mutation
Driver mutation
Online Access:https://doi.org/10.1186/s10020-023-00608-7

Internet

https://doi.org/10.1186/s10020-023-00608-7

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