Exploiting tumor epigenetics to improve oncolytic virotherapy

Exploiting tumor epigenetics to improve oncolytic virotherapy

Oncolytic viruses (OVs) comprise a versatile and multi-mechanistic therapeutic platform in the growing arsenal of anticancer biologics. These replicating therapeutics find favorable conditions in the tumor niche, characterized among others by increased metabolism, reduced anti-tumor/antiviral immuni...

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Bibliographic Details
Main Authors: Nicole E. Forbes, Hesham eAbdelbary, Mathieu eLupien, John C. Bell, Jean-Simon eDiallo
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-09-01
Series:Frontiers in Genetics
Subjects:
Antigen Presentation
Oncolytic Virotherapy
Cancer
tumor heterogeneity
Epigenetic Modulation
Anti-Viral Response
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00184/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00184/full

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