Interaction between Microsatellite Instability (MSI) and Tumor DNA Methylation in the Pathogenesis of Colorectal Carcinoma

Interaction between Microsatellite Instability (MSI) and Tumor DNA Methylation in the Pathogenesis of Colorectal Carcinoma

In colorectal cancer (CRC), the role of microsatellite instability (MSI) is well known. In a genome-wide scale, for the first time, we explored whether differential methylation is associated with MSI. We analyzed 250 paired samples from 125 CRC patients (m = 72, f = 53) at different stages. Of them,...

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Bibliographic Details
Main Authors: Farzana Jasmine, Zahidul Haq, Mohammed Kamal, Maruf Raza, Gustavo da Silva, Katrina Gorospe, Rupash Paul, Patrick Strzempek, Habibul Ahsan, Muhammad G Kibriya
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cancers
Subjects:
MSI
colorectal cancer
interaction
CIMP
MMR
immune checkpoint inhibitor
Online Access:https://www.mdpi.com/2072-6694/13/19/4956

Internet

https://www.mdpi.com/2072-6694/13/19/4956

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