Detection of EXP1-Specific CD4+ T Cell Responses Directed Against a Broad Range of Epitopes Including Two Promiscuous MHC Class II Binders During Acute Plasmodium falciparum Malaria

Detection of EXP1-Specific CD4+ T Cell Responses Directed Against a Broad Range of Epitopes Including Two Promiscuous MHC Class II Binders During Acute Plasmodium falciparum Malaria

Background: T cells are thought to play a major role in conferring immunity against malaria. This study aimed to comprehensively define the breadth and specificity of the Plasmodium falciparum (P. falciparum)-specific CD4+ T cell response directed against the exported protein 1 (EXP1) in a cohort of...

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Bibliographic Details
Main Authors: Janna Heide, Nils H. Wildner, Christin Ackermann, Melanie Wittner, Matthias Marget, Alessandro Sette, John Sidney, Thomas Jacobs, Julian Schulze zur Wiesch
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
malaria
Plasmodium falciparum
Plasmodium vivax
CD4+
CD8+
T cell epitope
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03037/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.03037/full

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