Proteome Profiling of RNF213 Depleted Cells Reveals Nitric Oxide Regulator DDAH1 Antilisterial Activity

Proteome Profiling of RNF213 Depleted Cells Reveals Nitric Oxide Regulator DDAH1 Antilisterial Activity

RNF213 is a large, poorly characterized interferon-induced protein. Mutations in RNF213 are associated with predisposition for Moyamoya disease (MMD), a rare cerebrovascular disorder. Recently, RNF213 was found to have broad antimicrobial activity in vitro and in vivo, yet the molecular mechanisms b...

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Bibliographic Details
Main Authors: Lia Martina, Caroline Asselman, Fabien Thery, Katie Boucher, Louis Delhaye, Teresa M. Maia, Bart Dermaut, Sven Eyckerman, Francis Impens
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Listeria
bacterial infection
Moyamoya
nitric oxide, NO
mass spectrometry
proteomics
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.735416/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2021.735416/full

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