Population Pharmacokinetics of Intravenous Acyclovir in Oncologic Pediatric Patients

Population Pharmacokinetics of Intravenous Acyclovir in Oncologic Pediatric Patients

Background: Acyclovir represents the first-line prophylaxis and therapy for herpes virus infections. However, its pharmacokinetics in children exposes them to the risk of ineffective or toxic concentrations. The study was aimed at investigating the population pharmacokinetics (POP/PK) of intravenous...

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Bibliographic Details
Main Authors: Natalia Maximova, Daniela Nisticò, Giacomo Luci, Roberto Simeone, Elisa Piscianz, Ludovica Segat, Egidio Barbi, Antonello Di Paolo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pharmacology
Subjects:
acyclovir
pediatric patients
hematopoietic stem cell transplantation
pharmacokinetics
non-linear mixed effect modeling
prolonged infusion acyclovir
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.865871/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.865871/full

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