Enhancing Dissolution and Oral Bioavailability of Ursodeoxycholic Acid with a Spray-Dried pH-Modified Extended Release Formulation

Enhancing Dissolution and Oral Bioavailability of Ursodeoxycholic Acid with a Spray-Dried pH-Modified Extended Release Formulation

Ursodeoxycholate (UDCA) has low oral bioavailability and pH-dependent solubility and permeability. Thus, we developed a pH-modified extended-release formulation of UDCA using Na<sub>2</sub>CO<sub>3</sub> as the alkalizing agent and hydroxypropyl methylcellulose (HPMC) as the...

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Bibliographic Details
Main Authors: Jaehyeok Lee, Chul Haeng Lee, Jong-Geon Lee, So Yeon Jeon, Min-Koo Choi, Im-Sook Song
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Pharmaceutics
Subjects:
ursodeoxycholate (UDCA)
oral bioavailability
pH-modified extended release formulation
spray-drying method
Online Access:https://www.mdpi.com/1999-4923/14/5/1037

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https://www.mdpi.com/1999-4923/14/5/1037

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