Tuberous Sclerosis Complex as Disease Model for Investigating mTOR-Related Gliopathy During Epileptogenesis

Tuberous Sclerosis Complex as Disease Model for Investigating mTOR-Related Gliopathy During Epileptogenesis

Tuberous sclerosis complex (TSC) represents the prototypic monogenic disorder of the mammalian target of rapamycin (mTOR) pathway dysregulation. It provides the rational mechanistic basis of a direct link between gene mutation and brain pathology (structural and functional abnormalities) associated...

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Bibliographic Details
Main Authors: Till S. Zimmer, Diede W. M. Broekaart, Victoria-Elisabeth Gruber, Erwin A. van Vliet, Angelika Mühlebner, Eleonora Aronica
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Neurology
Subjects:
tuberous sclerosis (TSC)
mammalian target of rapamycin (mTOR)
epilepsy
astrocyte
microglia
oligodendrocyte
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2020.01028/full

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https://www.frontiersin.org/article/10.3389/fneur.2020.01028/full

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