Inhibition of the TRIM24 bromodomain reactivates latent HIV-1

Abstract Expression of the HIV-1 genome by RNA Polymerase II is regulated at multiple steps, as are most cellular genes, including recruitment of general transcription factors and control of transcriptional elongation from the core promoter. We recently discovered that tripartite motif protein TRIM2...

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Bibliographic Details
Main Authors: Riley M. Horvath, Zabrina L. Brumme, Ivan Sadowski
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-27765-3