Lateral hypothalamus orexinergic projection to the medial prefrontal cortex modulates chronic stress-induced anhedonia but not anxiety and despair

Lateral hypothalamus orexinergic projection to the medial prefrontal cortex modulates chronic stress-induced anhedonia but not anxiety and despair

Abstract Chronic stress-induced anxiodepression is a common health problem, however its potential neurocircuitry mechanism remains unclear. We used behavioral, patch-clamp electrophysiology, chemogenetic, and optogenetic approaches to clarify the response of the lateral hypothalamus (LH) and the med...

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Bibliographic Details
Main Authors: Danlei Liu, Xuefeng Zheng, Yuqing Hui, Yuanyuan Xu, Jinjiang Du, Zean Du, Yichen Che, Fengming Wu, Guangyin Yu, Jifeng Zhang, Xiaobing Gong, Guoqing Guo
Format: Article
Language:English
Published: Nature Publishing Group 2024-03-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-024-02860-9

Internet

https://doi.org/10.1038/s41398-024-02860-9

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