Multifunctional, TNF-α and IFN-γ-Secreting CD4 and CD8 T Cells and CD8High T Cells Are Associated With the Cure of Human Visceral Leishmaniasis

Multifunctional, TNF-α and IFN-γ-Secreting CD4 and CD8 T Cells and CD8High T Cells Are Associated With the Cure of Human Visceral Leishmaniasis

Visceral leishmaniasis (VL) is a chronic and often fatal disease caused by protozoans of the genus Leishmania that affects millions of people worldwide. Patients with symptomatic VL have an impaired anti-Leishmania-specific CD4+ T-cell response, which is reversed after clinical cure. In contrast, th...

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Bibliographic Details
Main Authors: Lorranny Santana Rodrigues, Aline Silva Barreto, Lays Gisele Santos Bomfim, Marcos Couto Gomes, Nathalia Luisa Carlos Ferreira, Geydson Silveira da Cruz, Lucas Sousa Magalhães, Amélia Ribeiro de Jesus, Clarisa B. Palatnik-de-Sousa, Cristiane Bani Corrêa, Roque Pacheco de Almeida
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
cellular immunity
immunophenotyping
T-cell subsets
multifunctional
human visceral leishmaniasis
Leishmania (L.) infantum chagasi
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.773983/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.773983/full

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