Prospective identification of variables as outcomes for treatment (PIVOT): study protocol for a randomised, placebo-controlled trial of hydroxyurea for Ghanaian children and adults with haemoglobin SC disease

Prospective identification of variables as outcomes for treatment (PIVOT): study protocol for a randomised, placebo-controlled trial of hydroxyurea for Ghanaian children and adults with haemoglobin SC disease

Abstract Background Haemoglobin SC (HbSC) is a common form of sickle cell disease (SCD), especially among individuals of West African ancestry. Persons with HbSC disease suffer from the same clinical complications and reduced quality of life that affect those with sickle cell anaemia (HbSS/Sβ0). Ret...

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Bibliographic Details
Main Authors: Luke R. Smart, Catherine I. Segbefia, Teresa S. Latham, Susan E. Stuber, Kwesi N. Amissah-Arthur, Klenam Dzefi-Tettey, Adam C. Lane, Yvonne A. Dei-Adomakoh, Russell E. Ware
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Trials
Subjects:
Sickle cell disease
Haemoglobin SC disease
Hydroxyurea
Adults
Children
Online Access:https://doi.org/10.1186/s13063-023-07649-7

Internet

https://doi.org/10.1186/s13063-023-07649-7

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