α1-adrenoceptor stimulation ameliorates lipopolysaccharide-induced lung injury by inhibiting alveolar macrophage inflammatory responses through NF-κB and ERK1/2 pathway in ARDS

α1-adrenoceptor stimulation ameliorates lipopolysaccharide-induced lung injury by inhibiting alveolar macrophage inflammatory responses through NF-κB and ERK1/2 pathway in ARDS

IntroductionCatecholamines such as norepinephrine or epinephrine have been reported to participate in the development of acute respiratory distress syndrome (ARDS) by activating adrenergic receptors (ARs). But the role of α1-AR in this process has yet to be elucidated.MethodsIn this study, ARDS mous...

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Bibliographic Details
Main Authors: Zhukai Cong, Cui Yang, Zhaojin Zeng, Changyi Wu, Feng Zhao, Ziyuan Shen, Han Xiao, Xi Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
acute respiratory distress syndrome
α1 adrenergic receptor
alveolar macrophage
inflammation
NF-κb
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1090773/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1090773/full

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