Detection of Synergistic Interaction on an Additive Scale Between Two Drugs on Abnormal Elevation of Serum Alanine Aminotransferase Using Machine-Learning Algorithms

Detection of Synergistic Interaction on an Additive Scale Between Two Drugs on Abnormal Elevation of Serum Alanine Aminotransferase Using Machine-Learning Algorithms

Drug-induced liver injury (DILI) is a common adverse drug reaction, with abnormal elevation of serum alanine aminotransferase (ALT). Several clinical studies have investigated whether a combination of two drugs alters the reporting frequency of DILI using traditional statistical methods such as mult...

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Bibliographic Details
Main Authors: Hayato Akimoto, Takuya Nagashima, Kimino Minagawa, Takashi Hayakawa, Yasuo Takahashi, Satoshi Asai
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Pharmacology
Subjects:
machine-learning (ML) algorithms
liver function
drug induced liver injury (DILI)
alanine aminotransferase
drug interaction
relative excess risk due to interaction (RERI)
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.910205/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.910205/full

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