Thrombospondin-1 Partly Mediates the Cartilage Protective Effect of Adipose-Derived Mesenchymal Stem Cells in Osteoarthritis

Thrombospondin-1 Partly Mediates the Cartilage Protective Effect of Adipose-Derived Mesenchymal Stem Cells in Osteoarthritis

ObjectiveAssuming that mesenchymal stem cells (MSCs) respond to the osteoarthritic joint environment to exert a chondroprotective effect, we aimed at investigating the molecular response setup by MSCs after priming by osteoarthritic chondrocytes in cocultures.MethodsWe used primary human osteoarthri...

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Bibliographic Details
Main Authors: Marie Maumus, Cristina Manferdini, Karine Toupet, Paul Chuchana, Louis Casteilla, Mélanie Gachet, Christian Jorgensen, Gina Lisignoli, Danièle Noël
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
mesenchymal stem cells
trophic factors
thrombospondin
cell therapy
osteoarthritis
chondrogenesis
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01638/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01638/full

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