Peptide Blocking CTLA-4 and B7-1 Interaction

Peptide Blocking CTLA-4 and B7-1 Interaction

Discovery of the B7 family immune checkpoints such as CTLA-4 (CD152), PD-1 (CD279), as well as their ligands B7-1 (CD80), B7-2 (CD86), B7-H1 (PD-L1, CD274), and B7-DC (PD-L2, CD273), has opened new possibilities for cancer immunotherapy using monoclonal antibodies (mAb). The blockade of inhibitory r...

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Bibliographic Details
Main Authors: Stepan V. Podlesnykh, Kristina E. Abramova, Anastasia Gordeeva, Andrei I. Khlebnikov, Andrei I. Chapoval
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Molecules
Subjects:
peptides
immune checkpoints
peptide microarray
cancer
immunotherapy
Online Access:https://www.mdpi.com/1420-3049/26/2/253

Internet

https://www.mdpi.com/1420-3049/26/2/253

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