Sevoflurane exposure may cause dysplasia of dendritic spines and result in fine motor dysfunction in developing mouse through the PI3K/AKT/mTOR pathway

Sevoflurane exposure may cause dysplasia of dendritic spines and result in fine motor dysfunction in developing mouse through the PI3K/AKT/mTOR pathway

Sevoflurane has become one of the most widely used volatile anesthetics in pediatric surgery. However, sevoflurane exposure may interfere with dendritic development and synaptogenesis, resulting in brain function impairment. The PI3K/AKT/mTOR pathway plays an important role in dendritic development...

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Bibliographic Details
Main Authors: Linhong Zhong, Xiaofan Ma, Yixuan Niu, Lei Zhang, Zhenyu Xue, Jia Yan, Hong Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Neuroscience
Subjects:
sevoflurane
dendritic spine
PI3k/AKT/mTOR pathway
fine motor dysfunction
developing brain
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.1006175/full

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https://www.frontiersin.org/articles/10.3389/fnins.2022.1006175/full

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