TRPA1 promotes the maturation of embryonic stem cell-derived cardiomyocytes by regulating mitochondrial biogenesis and dynamics

TRPA1 promotes the maturation of embryonic stem cell-derived cardiomyocytes by regulating mitochondrial biogenesis and dynamics

Abstract Background Cardiomyocytes derived from pluripotent stem cells (PSC-CMs) have been widely accepted as a promising cell source for cardiac drug screening and heart regeneration therapies. However, unlike adult cardiomyocytes, the underdeveloped structure, the immature electrophysiological pro...

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Bibliographic Details
Main Authors: Qianqian Ding, Xianji Liu, Yanxiang Qi, Xiaoqiang Yao, Suk Ying Tsang
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Stem Cell Research & Therapy
Subjects:
Embryonic stem cell-derived cardiomyocytes
Cardiomyocyte maturation
Transient receptor potential ankyrin 1 channel
Mitochondria
Peroxisome proliferator-activated receptor gamma coactivator-1α
Online Access:https://doi.org/10.1186/s13287-023-03388-3

Internet

https://doi.org/10.1186/s13287-023-03388-3

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