Prediction of antipsychotics efficacy based on a polygenic risk score: a real-world cohort study

Prediction of antipsychotics efficacy based on a polygenic risk score: a real-world cohort study

Background: Response to antipsychotics is subject to a wide interindividual variability, due to genetic and non-genetic factors. Several single nucleotide polymorphisms (SNPs) have been associated with response to antipsychotics in genome-wide association studies (GWAS). Polygenic risk scores (PRS)...

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Bibliographic Details
Main Authors: Marco De Pieri, Marco Ferrari, Giorgio Pistis, Franziska Gamma, Franca Marino, Armin Von Gunten, Philippe Conus, Marco Cosentino, Chin-Bin Eap
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Pharmacology
Subjects:
antipsychotics
personalized medicine
GWAS
response to treatment
polygenic risk score
single nucleotide polimorphism (SNP)
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1274442/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1274442/full

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