Targeting the Ubiquinol-Reduction (Q<sub>i</sub>) Site of the Mitochondrial Cytochrome <i>bc<sub>1</sub></i> Complex for the Development of Next Generation Quinolone Antimalarials

Targeting the Ubiquinol-Reduction (Q<sub>i</sub>) Site of the Mitochondrial Cytochrome <i>bc<sub>1</sub></i> Complex for the Development of Next Generation Quinolone Antimalarials

Antimalarials targeting the ubiquinol-oxidation (Q<sub>o</sub>) site of the <i>Plasmodium falciparum</i> bc<sub>1</sub> complex, such as atovaquone, have become less effective due to the rapid emergence of resistance linked to point mutations in the Q<sub>o&...

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Bibliographic Details
Main Authors: Kangsa Amporndanai, Nattapon Pinthong, Paul M. O’Neill, W. David Hong, Richard K. Amewu, Chandrakala Pidathala, Neil G. Berry, Suet C. Leung, Stephen A. Ward, Giancarlo A. Biagini, S. Samar Hasnain, Svetlana V. Antonyuk
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Biology
Subjects:
antimalarial
<i>Plasmodium falciparum</i>
atovaquone
drug resistance
quinolone
<i>bc</i><sub>1</sub> inhibitor
Online Access:https://www.mdpi.com/2079-7737/11/8/1109

Internet

https://www.mdpi.com/2079-7737/11/8/1109

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