Paracrine Signals in Calcified Conditioned Media Elicited Differential Responses in Primary Aortic Vascular Smooth Muscle Cells and in Adventitial Fibroblasts

Paracrine Signals in Calcified Conditioned Media Elicited Differential Responses in Primary Aortic Vascular Smooth Muscle Cells and in Adventitial Fibroblasts

Our goal was to determine if paracrine signals from different aortic layers can impact other cell types in the diabetic microenvironment, specifically medial vascular smooth muscle cells (VSMCs) and adventitial fibroblasts (AFBs). The diabetic hyperglycemic aorta undergoes mineral dysregulation, cau...

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Bibliographic Details
Main Authors: Amber M. Kennon, James A. Stewart
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
vascular calcification
diabetes mellitus
vascular smooth muscle cells
adventitial fibroblasts
receptor for advanced glycation end-products (RAGEs)
conditioned media
Online Access:https://www.mdpi.com/1422-0067/24/4/3599

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https://www.mdpi.com/1422-0067/24/4/3599

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