Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit

Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit

Ribonucleotide reductases (RNRs) are key enzymes in DNA metabolism, with allosteric mechanisms controlling substrate specificity and overall activity. In RNRs, the activity master-switch, the ATP-cone, has been found exclusively in the catalytic subunit. In two class I RNR subclasses whose catalytic...

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Bibliographic Details
Main Authors: Inna Rozman Grinberg, Daniel Lundin, Mahmudul Hasan, Mikael Crona, Venkateswara Rao Jonna, Christoph Loderer, Margareta Sahlin, Natalia Markova, Ilya Borovok, Gustav Berggren, Anders Hofer, Derek T Logan, Britt-Marie Sjöberg
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-02-01
Series:eLife
Subjects:
Leewenhoekiella blandensis
ribonucleotide reductase
allosteric regulation
dATP inhibition
ATP-cone
oligomerization
Online Access:https://elifesciences.org/articles/31529

Internet

https://elifesciences.org/articles/31529

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