Blocking Jak/STAT signalling using tofacitinib inhibits angiogenesis in experimental arthritis

Blocking Jak/STAT signalling using tofacitinib inhibits angiogenesis in experimental arthritis

Abstract Objective During rheumatoid arthritis (RA), the angiogenic processes, occurring with pannus-formation, may be a therapeutic target. JAK/STAT-pathway may play a role and the aim of this work was to investigate the inhibiting role of a JAK-inhibitor, tofacitinib, on the angiogenic mechanisms...

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Bibliographic Details
Main Authors: Paola Di Benedetto, Piero Ruscitti, Onorina Berardicurti, Noemi Panzera, Nicolò Grazia, Mauro Di Vito Nolfi, Barbara Di Francesco, Luca Navarini, Antonio Maurizi, Nadia Rucci, Anna Maria Teti, Francesca Zazzeroni, Giuliana Guggino, Francesco Ciccia, Vincenza Dolo, Edoardo Alesse, Paola Cipriani, Roberto Giacomelli
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Arthritis Research & Therapy
Subjects:
Rheumatoid arthritis
Angiogenesis
Tofacitinib
Online Access:https://doi.org/10.1186/s13075-021-02587-8

Internet

https://doi.org/10.1186/s13075-021-02587-8

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