TDP-43 expression influences amyloidβ plaque deposition and tau aggregation

TDP-43 expression influences amyloidβ plaque deposition and tau aggregation

Although the main focus in Alzheimer's disease (AD) has been an investigation of mechanisms causing Aβ plaque deposition and tau tangle formation, recent studies have shown that phosphorylated TDP-43 pathology is present in up to 50% of sporadic cases. Furthermore, elevated phosphorylated TDP-4...

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Bibliographic Details
Main Authors: Stephani A. Davis, Kok Ann Gan, James A. Dowell, Nigel J. Cairns, Michael A. Gitcho
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Neurobiology of Disease
Subjects:
TDP-43
TARDBP
APP
Calcineurin
Alzheimer's disease
APP/PS1
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117300864

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http://www.sciencedirect.com/science/article/pii/S0969996117300864

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