NRF2-Dependent Placental Effects Vary by Sex and Dose following Gestational Exposure to Ultrafine Particles

NRF2-Dependent Placental Effects Vary by Sex and Dose following Gestational Exposure to Ultrafine Particles

Exposure to ultrafine particles (UFPs, PM<sub>0.1</sub>) during pregnancy triggers placental oxidative stress and inflammation, similar to fine PM (PM<sub>2.5</sub>). The <i>Nrf2</i> gene encodes a redox-sensitive transcription factor that is a major regulator of...

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Bibliographic Details
Main Authors: Jonathan C. Behlen, Carmen H. Lau, Drew Pendleton, Yixin Li, Aline Rodrigues Hoffmann, Michael C. Golding, Renyi Zhang, Natalie M. Johnson
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Antioxidants
Subjects:
air pollution
ultrafine particulate matter
developmental toxicology
placenta
gestational exposure
<i>Nrf2</i>
Online Access:https://www.mdpi.com/2076-3921/11/2/352

Internet

https://www.mdpi.com/2076-3921/11/2/352

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