Total and Free Blood and Plasma Concentration Changes in Pregnancy for Medicines Highly Bound to Plasma Proteins: Application of Physiologically Based Pharmacokinetic Modelling to Understand the Impact on Efficacy

Total and Free Blood and Plasma Concentration Changes in Pregnancy for Medicines Highly Bound to Plasma Proteins: Application of Physiologically Based Pharmacokinetic Modelling to Understand the Impact on Efficacy

Free drug concentrations are generally considered the pharmacologically active moiety and are important for cellular diffusion and distribution. Pregnancy-related changes in plasma protein binding and blood partitioning are due to decreases in plasma albumin, alpha-1-acid glycoprotein, and haematocr...

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Bibliographic Details
Main Authors: Paola Coppola, Andrew Butler, Susan Cole, Essam Kerwash
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Pharmaceutics
Subjects:
pharmacokinetics
pregnancy
protein binding
free concentrations
total concentrations
PBPK
Online Access:https://www.mdpi.com/1999-4923/15/10/2455

Internet

https://www.mdpi.com/1999-4923/15/10/2455

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