[18F]-THK5351 PET Correlates with Topology and Symptom Severity in Progressive Supranuclear Palsy

[18F]-THK5351 PET Correlates with Topology and Symptom Severity in Progressive Supranuclear Palsy

Progressive supranuclear palsy (PSP) is a neurodegenerative movement disorder characterized by deposition of fibrillar aggregates of 4R tau-protein in neurons and glial cells of the brain. These deposits are a key neuropathological finding, allowing a diagnosis of “definite PSP,” which is usually es...

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Bibliographic Details
Main Authors: Matthias Brendel, Sonja Schönecker, Günter Höglinger, Simon Lindner, Joachim Havla, Janusch Blautzik, Julia Sauerbeck, Guido Rohrer, Christian Zach, Franziska Vettermann, Anthony E. Lang, Lawrence Golbe, Georg Nübling, Peter Bartenstein, Katsutoshi Furukawa, Aiko Ishiki, Kai Bötzel, Adrian Danek, Nobuyuki Okamura, Johannes Levin, Axel Rominger
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Aging Neuroscience
Subjects:
PET
[18F]-THK5351
progressive supranuclear palsy
PSPRS
disease severity
Online Access:http://journal.frontiersin.org/article/10.3389/fnagi.2017.00440/full

Internet

http://journal.frontiersin.org/article/10.3389/fnagi.2017.00440/full

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