Fluorescein-based sensors to purify human α-cells for functional and transcriptomic analyses

Fluorescein-based sensors to purify human α-cells for functional and transcriptomic analyses

Pancreatic α-cells secrete glucagon, an insulin counter-regulatory peptide hormone critical for the maintenance of glucose homeostasis. Investigation of the function of human α-cells remains a challenge due to the lack of cost-effective purification methods to isolate high-quality α-cells from islet...

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Bibliographic Details
Main Authors: Sevim Kahraman, Kimitaka Shibue, Dario F De Jesus, Hyunki Kim, Jiang Hu, Debasish Manna, Bridget Wagner, Amit Choudhary, Rohit N Kulkarni
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-09-01
Series:eLife
Subjects:
α-cells
pseudoislets
human pancreatic islets
diabetes
Online Access:https://elifesciences.org/articles/85056

Internet

https://elifesciences.org/articles/85056

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